Antibiotic treatment failure against life-threatening bacterial pathogens is typically caused by the rapid emergence and dissemination of antibiotic resistance.The current lack of antibiotic discovery and development urgently calls for new strategies to combat multidrug-resistant (MDR) bacteria, especially those that survive in host cells.Functiona
In the nematode C.elegans, insulin signaling regulates development and aging in response to the secretion of numerous insulin peptides.Here, we describe a novel, non-signaling isoform of the nematode insulin receptor (IR), DAF-2B, that modulates insulin signaling by sequestration of insulin peptides.DAF-2B arises via alternative splicing and retain
When placed on a temperature gradient, a Drosophila larva navigates away from excessive cold or heat by regulating the size, frequency, and Bar Tables direction of reorientation maneuvers between successive periods of forward movement.Forward movement is driven by peristalsis waves that travel from tail to head.During each reorientation maneuver, t
Numerous studies have investigated the long-term variability in surface solar radiation (SSR) around the world.However, the large disparity in the availability of observational cereal box data between developed and less developed/developing countries leads to an under-representation of studies on SSR changes in the latter.This is especially true fo